The Relationship of CSF and Plasma Cytokine Levels in HIV Infected Patients with Neurocognitive Impairment

Figure 1

Comparison of G-CSF, IL-8, IP-10, and MCP-1 concentrations in paired CSF and plasma samples from 33 HIV infected subjects with normal cognition (HIV-NC) and 52 HIV infected subjects with cognition impairment (HIV-CI). Values below the lower limit of detection of the assay are reported as zero. The levels of G-CSF, IL-8, IP-10, and MCP-1 in CSF from HIV-CI group were significantly higher than HIV-NC group (a), whereas in plasma samples, only G-CSF and IP-10 showed significant difference (b). Differences were analyzed by the Mann-Whitney test. values of <0.05 were considered significant. Dots, cytokine level in CSF for each study subject; horizontal lines, median values for each group.

(a)

(b)