The Relationship of CSF and Plasma Cytokine Levels in HIV Infected Patients with Neurocognitive Impairment

Table 2

Cytokine concentrations in paired CSF and plasma samples.

	HIV-CI				HIV-NC
	Plasma	CSF	Wilcoxon signed rank,	Correlation coefficient^*	Plasma	CSF	Wilcoxon signed rank,	Correlation coefficient^*
Eotaxin
Median	78.86	0.94	<0.0001		59.36	0.79	0.0019	−0.6241
IQR	15.88–202.3	0–45.9		= 0.0038	6.54–200.4	0–1.165		= 0.0001
<Detection Limit	2%	56%			0%	37%
G-CSF
Median	234.8	207	0.4255	0.1667	64.3	4.36	0.2436	0.5353
IQR	31.54–421.5	26.53–415.2		= 0.2375	17.62–287.5	0–279.2		P = 0.0013
<Detection Limit	4%	13%			8%	27%
IFN-α2
Median	29.03	66.79	0.0039	0.6903	10.82	40.58	0.0174	0.4831
IQR	5.59–80.2	0.74–175.7		< 0.0001	0–55.05	0–104.6		P = 0.0044
<Detection Limit	10%	25%			23%	17%
IL-8
Median	4.78	100.6	<0.0001	−0.07862	1.47	22.44	<0.0001	0.1896
IQR	0.71–13.82	8.86–343.4		= 0.5796	0.375–12.82	5.92–102.4		P = 0.2907
<Detection Limit	29%	4%			29%	2%
IP-10
Median	2985	17260	<0.0001	0.7525	1845	5834	0.001	0.1756
IQR	1451–6428	1828–51620		< 0.0001	1046–3891	2521–11330		P = 0.3364
<Detection Limit	0%	6%			0%	2%
MCP-1
Median	292.1	1755	<0.0001	0.1527	289.4	1120	<0.0001	0.08761
IQR	144–502.9	692.9–3147		= 0.2798	60.25–550.8	526.9–2294		P = 0.6335
<Detection Limit	0%	4%			0%	2%

Spearman rank correlation, values below the lower limits of detection set at zero.