S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease

Figure 1

(a) Western blot and (b–f) densitometric analysis (arbitrary units normalized on the expression of the housekeeping protein -actin) showing the effect of 7 days of intrahippocampal injection of pentamidine (0.05–5 g/mL/day) on GFAP (b), iNOS (c), p-p38 MAPK (d), COX-2 (e), and RAGE (f) expression in A-injected mice. Results are expressed as mean ± SEM of experiments performed in triplicate. versus vehicle-treated mice; , and versus A-treated mice.

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