Osteopontin Involves Cisplatin Resistance and Poor Prognosis in Oral Squamous Cell Carcinoma

Figure 3

OPN promoted cell proliferation and drove cisplatin resistance in an oral cancer cell line. (a) SAS cells stimulated with OPN protein promoted cell growth. SAS cells were treated with indicated concentrations of OPN, and cell growth was analyzed on days 1–4 by MTT assay. Data were normalized against the OD₅₇₀ value on day 1 of each treatment. The results represent the mean ± SD of three independent experiments. (b) OPN affected the chemosensitivity of OSCC cells to cisplatin. SAS cells were cultured in the presence or absence cisplatin and/or OPN in a dose-dependent manner, and their viability was measured. (c) OPN stimulated SAS cells were incubated with increasing concentrations of cisplatin for 72 hours, and their viability was measured and was expressed in percentage.

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