Variations in Antioxidant Genes and Male Infertility

Table 2

Reported antioxidant genetic variations associated with male infertility.

Gene	Variation	Official description	Trait/effect	Species	Reference
NRF2	Deletion	—	Subfertility	Mice	[7]
	rs6721961 G>T	NC_000002.11:g.178130037 T>G	Oligoasthenozoospermia	Human	[20]
	rs35652124T>C	NC_000002.11:g.178130073 T>C	Oligoasthenozoospermia	Human	[20]
	rs6721961 G>T + smoking	NC_000002.11:g.178130037 T>G	Sperm concentration and count	Human	[12]
GST	GSTM1-null	Deletion	Male infertility, oligozoospermia, male infertility with varicocele	Human	[21–28]
	GSTT1-null	Deletion	Male infertility, male infertility with varicocele	Human	[24, 26–32]
	GSTM1 rs135955605 C/G	—	Sperm motility after cryopreservation	Bulls	[33]
	GSTP1 (Ile105Val)	NC_000011.10:g.67585218 A>G	Male infertility, oligospermia, oligoasthenoteratozoospermia, azoospermia	Human	[26, 31, 34]
	GSTP1 (Ala114Val)	NC_000011.10:g.67586108 C>T	Male infertility with varicocele, oligoasthenoteratozoospermia	Human	[27, 34]
	GSTM1-null + PAH exposure	Deletion	PAH-DNA adducts	Human	[35]
	GSTM1-null/GSTT1-null + smoking	Deletion	Idiopathic male infertility	Human	[36]
	GSTM1-null + CYP1A1	Deletion	Male infertility	Human	[37]
SOD	SOD2 rs4880 CC	NC_000006.11:g.160113872 A>G	Idiopathic infertility, male infertility, pregnancy rates in IVF, sperm concentration, sperm motility, and sperm DNA fragmentation	Human	[38–41]
	SOD1 knockout	—	Male infertility	Drosophila	[42]
	SOD1 knockout	—	Spermatogenic cell damage during heat stress	Mice	[43]
CAT	C-262T	NC_000011.10:g.34438684 C>T	Idiopathic male infertility	Human	[44]
NOS	eNOS T786C	NC_000007.13:g.150690079 C>T	Male infertility, oligoasthenoteratozoospermia, idiopathic male infertility	Human	[45–47]
	eNOS G894T	NC_000007.13:g.150696111 T>G, NP_001153582.1:p.Asp298Glu,	Oligoasthenoteratozoospermia, asthenozoospermia, idiopathic male infertility	Human	[46–50]
	eNOS 4a/b	NC_000007.14:g.150997188_150997214-AGGGGTGAGGAAGTCTAGACCTGCTGC2)3)	Idiopathic male infertility, sperm morphology	Human	[45, 47, 51]
GPX	GPX4 deletion	—	Male infertility, sperm chromatin condensation	Mice	[52, 53]
	GPX5 deletion	—	Sperm DNA integrity	Mice	[54]