Integrative Analysis of CRISPR/Cas9 Target Sites in the Human HBB Gene

Figure 2

Phylogenetic analysis of β-like globins (a) Structure model of the β-globin gene cluster in H. sapiens and G. gallus. Adult genes are shown in red, fetal genes in green, embryonic genes in blue, and pseudogenes in pink. (b) Amino acid sequences and alignment result of -like globins from H. sapiens, P. troglodytes, G. gallus, and C. moschata. (c) Cladogram of -like globin sequences. HBB, hemoglobin subunit ; HBE, hemoglobin subunit ; HBD, hemoglobin subunit ; HBG1, hemoglobin subunit -1; HBG2, hemoglobin subunit -2.

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