The Use of an IL-1 Receptor Antagonist Peptide to Control Inflammation in the Treatment of Corneal Limbal Epithelial Stem Cell Deficiency

Figure 4

Peptide suppression of IL-6 and IL-8 production by LPS-stimulated keratocytes. (a) IL-8 and (b) IL-6 were secreted by keratocytes when stimulated with 0.02 μg/mL LPS and a range of peptide concentrations (0.001–1000 μg/mL). The addition of 1000 μg/mL peptide resulted in a significant reduction in cytokine secretion . (, mean ± sd). Peptide (1000 μg/mL) with no cells, peptide (1000 μg/mL) and LPS (0.02 μg/mL) without cells, and Triton-X and cells were included as controls.

(a)

(b)