The Use of an IL-1 Receptor Antagonist Peptide to Control Inflammation in the Treatment of Corneal Limbal Epithelial Stem Cell Deficiency

Figure 5

Peptide suppression of cytokine production by IL-1β stimulated keratocytes. (a) IL-8 and (b) IL-6 secretion by keratocytes stimulated with IL-1β (10⁻⁹ M) and a range of peptide concentrations (0.001–1000 μg/mL) was significantly reduced following addition of 1000 μg/mL peptide when compared to the group containing no peptide (). (c) IL-1β secretion by keratocytes stimulated with IL-1β (10⁻⁹ M) and a range of peptide concentrations (0.001–1000 μg/mL) showed significant differences in cytokine secretion at 0.01 μg/mL and 1000 μg/mL compared to the no peptide added controls (, mean ± sd).

(a)

(b)

(c)