The Effect of MGCD0103 on CYP450 Isoforms Activity of Rats by Cocktail Method

Figure 1

The pharmacokinetic profiles of bupropion (a), omeprazole (b), phenacetin (c), testosterone (d), tolbutamide (e), and metoprolol (f) in control group and MGCD0103 group (low, medium, and high) rats (). From the result, no difference in pharmacokinetic behaviors can be observed between low, medium dosage group and control group. On the other hand, no significant difference for AUC, of omeprazole, phenacetin, metoprolol, testosterone, and bupropion () between the high dosage group and control group was observed. However, the pharmacokinetic parameters of tolbutamide experienced obvious change with decreased () and increased CL () after the dosage increase.

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