Table 1: Pharmacokinetic parameters of bupropion and omeprazole from control group and MGCD0103 group rats (mean ± SD, n = 10).

ParametersCL
ng/mLhng/mLhhL/h/kgL/kgng/mL

Bupropion
 Low282.5 ± 403.2324.2 ± 506.30.8 ± 0.4128.3 ± 141.5149.6 ± 187.0156.7 ± 179.0
 Medium120.4 ± 45.1122.3 ± 45.20.6 ± 0.290.6 ± 28.280.7 ± 52.998.5 ± 28.9
 High218.2 ± 460.8235.2 ± 502.80.9 ± 0.5200.6 ± 132.2249.2 ± 205.6156.1 ± 315.5
 Control144.8 ± 94.1146.7 ± 95.10.6 ± 0.1107.7 ± 87.6110.2 ± 119.6116.5 ± 93.7
Omeprazole
 Low700.1 ± 910.2704.9 ± 909.50.9 ± 0.329.1 ± 16.642.7 ± 32.0556.4 ± 646.0
 Medium526.1 ± 251.2539.1 ± 252.50.9 ± 0.622.3 ± 10.032.6 ± 24.3610.5 ± 280.0
 High676.8 ± 1111.6731.8 ± 1098.81.1 ± 0.431.8 ± 19.052.3 ± 34.7682.5 ± 1232.1
 Control503.8 ± 199.4528.0 ± 190.01.4 ± 1.021.2 ± 7.645.9 ± 38.4745.9 ± 416.8