The Effect of MGCD0103 on CYP450 Isoforms Activity of Rats by Cocktail Method

Table 1

Pharmacokinetic parameters of bupropion and omeprazole from control group and MGCD0103 group rats (mean ± SD, n = 10).

Parameters				CL
	ng/mLh	ng/mLh	h	L/h/kg	L/kg	ng/mL
Bupropion
Low	282.5 ± 403.2	324.2 ± 506.3	0.8 ± 0.4	128.3 ± 141.5	149.6 ± 187.0	156.7 ± 179.0
Medium	120.4 ± 45.1	122.3 ± 45.2	0.6 ± 0.2	90.6 ± 28.2	80.7 ± 52.9	98.5 ± 28.9
High	218.2 ± 460.8	235.2 ± 502.8	0.9 ± 0.5	200.6 ± 132.2	249.2 ± 205.6	156.1 ± 315.5
Control	144.8 ± 94.1	146.7 ± 95.1	0.6 ± 0.1	107.7 ± 87.6	110.2 ± 119.6	116.5 ± 93.7
Omeprazole
Low	700.1 ± 910.2	704.9 ± 909.5	0.9 ± 0.3	29.1 ± 16.6	42.7 ± 32.0	556.4 ± 646.0
Medium	526.1 ± 251.2	539.1 ± 252.5	0.9 ± 0.6	22.3 ± 10.0	32.6 ± 24.3	610.5 ± 280.0
High	676.8 ± 1111.6	731.8 ± 1098.8	1.1 ± 0.4	31.8 ± 19.0	52.3 ± 34.7	682.5 ± 1232.1
Control	503.8 ± 199.4	528.0 ± 190.0	1.4 ± 1.0	21.2 ± 7.6	45.9 ± 38.4	745.9 ± 416.8