Table 2: Pharmacokinetic parameters of phenacetin and testosterone in control group and MGCD0103 group rats (mean ± SD, n = 10).

ParametersCL
ng/mLhng/mLhhL/h/kgL/kgng/mL

Phenacetin
 Low2973.6 ± 1807.02975.9 ± 1806.60.6 ± 0.46.9 ± 7.76.4 ± 8.22878.6 ± 1629.1
 Medium2910.1 ± 1758.52918.2 ± 1751.40.6 ± 0.34.9 ± 3.24.5 ± 4.63185.1 ± 1617.4
 High2869.8 ± 3189.92871.9 ± 3189.00.6 ± 0.28.5 ± 7.49.5 ± 10.02038.8 ± 1958.2
 Control3831.2 ± 2840.93833.6 ± 2839.30.5 ± 0.24.2 ± 3.23.4 ± 3.53151.5 ± 1872.9
Testosterone
 Low404.5 ± 908.2417.2 ± 927.81.7 ± 0.8104.8 ± 49.0259.1 ± 168.6302.1 ± 630.9
 Medium81.3 ± 28.8106.5 ± 45.12.2 ± 2.4109.0 ± 43.8253.2 ± 204.393.2 ± 75.3
 High490.7 ± 1044.2524.5 ± 1042.44.0 ± 7.164.9 ± 33.4254.0 ± 291.0 461.8 ± 1032.1
 Control85.9 ± 40.689.9 ± 43.91.0 ± 0.6143.8 ± 89.6161.1 ± 82.288.1 ± 54.2

MGCD0103 group was compared with the control group, < 0.05.