The Effect of MGCD0103 on CYP450 Isoforms Activity of Rats by Cocktail Method

Table 2

Pharmacokinetic parameters of phenacetin and testosterone in control group and MGCD0103 group rats (mean ± SD, n = 10).

Parameters				CL
	ng/mLh	ng/mLh	h	L/h/kg	L/kg	ng/mL
Phenacetin
Low	2973.6 ± 1807.0	2975.9 ± 1806.6	0.6 ± 0.4	6.9 ± 7.7	6.4 ± 8.2	2878.6 ± 1629.1
Medium	2910.1 ± 1758.5	2918.2 ± 1751.4	0.6 ± 0.3	4.9 ± 3.2	4.5 ± 4.6	3185.1 ± 1617.4
High	2869.8 ± 3189.9	2871.9 ± 3189.0	0.6 ± 0.2	8.5 ± 7.4	9.5 ± 10.0	2038.8 ± 1958.2
Control	3831.2 ± 2840.9	3833.6 ± 2839.3	0.5 ± 0.2	4.2 ± 3.2	3.4 ± 3.5	3151.5 ± 1872.9
Testosterone
Low	404.5 ± 908.2	417.2 ± 927.8	1.7 ± 0.8	104.8 ± 49.0	259.1 ± 168.6	302.1 ± 630.9
Medium	81.3 ± 28.8	106.5 ± 45.1	2.2 ± 2.4	109.0 ± 43.8	253.2 ± 204.3	93.2 ± 75.3
High	490.7 ± 1044.2	524.5 ± 1042.4	4.0 ± 7.1	64.9 ± 33.4	254.0 ± 291.0	461.8 ± 1032.1
Control	85.9 ± 40.6	89.9 ± 43.9	1.0 ± 0.6	143.8 ± 89.6	161.1 ± 82.2	88.1 ± 54.2

MGCD0103 group was compared with the control group, < 0.05.