The Effect of MGCD0103 on CYP450 Isoforms Activity of Rats by Cocktail Method

Table 3

Pharmacokinetic parameters of tolbutamide and metoprolol in control group and MGCD0103 group rats (mean ± SD, n = 10).

Parameters				CL
	ng/mLh	ng/mLh	h	L/h/kg	L/kg	ng/mL
Tolbutamide
Low	82724.8 ± 13265.9	83176.9 ± 13264.2	5.2 ± 1.2	0.012 ± 0.002	0.090 ± 0.014	7939.9 ± 1199.1
Medium	72448.6 ± 14850.4	72761.4 ± 14754.7	4.7 ± 1.0	0.014 ± 0.003	0.093 ± 0.010	8038.6 ± 1318.2
High	64052.9 ± 15988.6	64353.2 ± 15998.9	4.4 ± 1.2	0.016 ± 0.003	0.099 ± 0.020	6208.9 ± 1115.5
Control	88701.2 ± 19274.8	89852.0 ± 19168.1	5.3 ± 0.7	0.012 ± 0.004	0.088 ± 0.019	7343.2 ± 1447.5
Metoprolol
Low	698.1 ± 348.6	703.8 ± 351.6	0.8 ± 0.1	18.2 ± 10.5	21.6 ± 13.5	370.7 ± 161.1
Medium	836.1 ± 499.8	843.7 ± 498.4	0.7 ± 0.3	14.1 ± 4.8	15.7 ± 9.1	520.9 ± 300.9
High	1031.8 ± 1261.2	1046.4 ± 1258.4	1.2 ± 0.4	22.9 ± 17.4	43.6 ± 39.6	1185.3 ± 2379.0
Control	709.2 ± 255.8	724.2 ± 255.8	0.8 ± 0.2	15.8 ± 6.7	18.0 ± 8.6	426.1 ± 159.3

MGCD0103 group was compared with the control group, < 0.05.