Table 3: Pharmacokinetic parameters of tolbutamide and metoprolol in control group and MGCD0103 group rats (mean ± SD, n = 10).

ParametersCL
ng/mLhng/mLhhL/h/kgL/kgng/mL

Tolbutamide
 Low82724.8 ± 13265.983176.9 ± 13264.25.2 ± 1.20.012 ± 0.0020.090 ± 0.0147939.9 ± 1199.1
 Medium72448.6 ± 14850.472761.4 ± 14754.74.7 ± 1.00.014 ± 0.0030.093 ± 0.0108038.6 ± 1318.2
 High64052.9 ± 15988.664353.2 ± 15998.94.4 ± 1.20.016 ± 0.0030.099 ± 0.0206208.9 ± 1115.5
 Control88701.2 ± 19274.889852.0 ± 19168.15.3 ± 0.70.012 ± 0.0040.088 ± 0.0197343.2 ± 1447.5
Metoprolol
 Low698.1 ± 348.6703.8 ± 351.60.8 ± 0.118.2 ± 10.521.6 ± 13.5370.7 ± 161.1
 Medium836.1 ± 499.8843.7 ± 498.40.7 ± 0.314.1 ± 4.815.7 ± 9.1520.9 ± 300.9
 High1031.8 ± 1261.21046.4 ± 1258.41.2 ± 0.422.9 ± 17.443.6 ± 39.61185.3 ± 2379.0
 Control709.2 ± 255.8724.2 ± 255.80.8 ± 0.215.8 ± 6.718.0 ± 8.6426.1 ± 159.3

MGCD0103 group was compared with the control group, < 0.05.