A Randomized, Double-Blind Pilot Study of Dose Comparison of Ramosetron to Prevent Chemotherapy-Induced Nausea and Vomiting

Table 2

Pharmacokinetic parameters of ramosetron after a single intravenous injection of 0.3, 0.45, and 0.6 mg of ramosetron.

	0.3 mg	0.45 mg	0.6 mg
	( = 17)	( = 15)	( = 18)
(ng/mL)	3.2 ± 1.3	4.9 ± 3.3	7.3 ± 9.3
(h)	0.67	0.67	0.67
AUClast (ng⋅h/mL)	17.9 ± 6.9	25.9 ± 16.0	35.2 ± 34.8
(h)	6.4 ± 2.2	6.5 ± 3.2	6.4 ± 1.8
CL (L/h)	17.1 ± 6.6	21.3 ± 13.6	22.5 ± 11.8
(L)	110.6 ± 38.7	128.5 ± 60.6	142.3 ± 86.6

Data are presented as mean ± standard deviation.
, maximum concentration; /D, maximum concentration/dose; , time to ; AUC_last, area under the concentration-time curve of ramosetron from zero to the last measurable concentration; AUC_last/D, area under the concentration-time curve of ramosetron from zero to the last measurable concentration/dose; , terminal half-life; CL, clearance; , volume of distribution at steady state.