Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 526524, 9 pages
http://dx.doi.org/10.1155/2015/526524
Review Article

Functional Roles of Calreticulin in Cancer Biology

Yi-Chien Lu,1,2,3 Wen-Chin Weng,1,4 and Hsinyu Lee1,5,6,7

1Department of Life Science, National Taiwan University, Taipei 106, Taiwan
2Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan
3Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
4Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
5Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei 116, Taiwan
6Center for Biotechnology, National Taiwan University, Taipei 116, Taiwan
7Angiogenesis Research Center, National Taiwan University, Taipei 116, Taiwan

Received 19 December 2014; Revised 4 March 2015; Accepted 5 March 2015

Academic Editor: Marlene Benchimol

Copyright © 2015 Yi-Chien Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [41 citations]

The following is the list of published articles that have cited the current article.

  • Anna Fernández, Raquel Ordóñez, Russel J. Reiter, Javier González-Gallego, and José L. Mauriz, “Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis,” Journal of Pineal Research, 2015. View at Publisher · View at Google Scholar
  • Namita Pendharkar, Akshada Gajbhiye, Khushman Taunk, Sourav Roy Choudhury, Snigdha Dhali, Shubhendu Seal, Anupama Mane, Subodhini Abhang, Manas K. Santra, Koel Chaudhury, and Srikanth Rapole, “Quantitative tissue proteomic investigation of invasive ductal carcinoma of breast with luminal B HER2 positive and HER2 enriched subtypes towards potential diagnostic and therapeutic biomarkers,” Journal of Proteomics, 2015. View at Publisher · View at Google Scholar
  • Galia Ramírez-Toloza, Paula Abello, and Arturo Ferreira, “Is the Antitumor Property of Trypanosoma cruzi Infection Mediated by Its Calreticulin?,” Frontiers in Immunology, vol. 7, 2016. View at Publisher · View at Google Scholar
  • Robert F. Stanley, and Ulrich Steidl, “Molecular Mechanism of Mutant CALR-Mediated Transformation,” Cancer Discovery, vol. 6, no. 4, pp. 344–346, 2016. View at Publisher · View at Google Scholar
  • Rui-Qing Peng, Dan-Dan Li, Ya Ding, Xing Zhang, Xiao-Shi Zhang, and Xiao-Jun Wu, “Influences of combination of chemotherapy and autophagy inhibitor on the calreticulin expression in colon cancer cells,” Medical Journal of Chinese People's Liberation Army, vol. 41, no. 4, pp. 273–278, 2016. View at Publisher · View at Google Scholar
  • Emma Reeves, and Edward James, “Antigen processing and immune regulation in the response to tumours,” Immunology, vol. 150, no. 1, pp. 16–24, 2016. View at Publisher · View at Google Scholar
  • Stefano Molica, Giovanna Digiesi, Giovanni D'Arena, Rosanna Mirabelli, Anna Antenucci, Laura Conti, Massimo Gentile, Pellegrino Musto, Antonino Neri, and Fortunato Morabito, “Serum levels of soluble calreticulin predict for time to first treatment in early chronic lymphocytic leukaemia,” British Journal of Haematology, 2016. View at Publisher · View at Google Scholar
  • Manfredini, Romualdi, Guglielmelli, Balliu, Bartalucci, Pizzini, Bogani, Fanelli, Guglielmelli, Pieri, Bisognin, Bortoluzzi, Saccoman, Giovani, Badalucco, Balduini, Catarsi, Lupo, Massa, Villani, Catricalà, Elena, Gallì, Malcovati, Pascutto, Rossi, Rumi, Corada, Erba, Barbui, Gritti, Belotti, Boroni, Cilloni, Carturan, Guerrasio, Salati, Tagliafico, Zini, Zini, Calura, Norfo, Pennucci, Vannucchi, Bortoluzzi, Vannucchi, Bosi, Fjerza, Mannarelli, Martinelli, Pancrazzi, Paoli, Bisognin, Coppe, Masciulli, Azzan, Bonetti, Coppe, Campanelli, Isgrò, Magrini, Poletto, Rosti, Cazzola, Sales, Ambaglio, Bernasconi, Casetti, Fugazza, Milanesi, Gaffo, Pietra, Ripamonti, Dejana, Breviario, Rambaldi, Fanelli, Ferrari, Finazzi, Finazzi, Salmoiraghi, Amaru, Golay, Mannarelli, Campia, Manfredini, Bianchi, Montanari, and Tenedini, “A data-driven network model of primary myelofibrosis: Transcriptional and post-transcriptional alterations in CD34+ cells,” Blood Cancer Journal, vol. 6, no. 6, 2016. View at Publisher · View at Google Scholar
  • Reuther, “Myeloproliferative Neoplasms: Molecular Drivers and Therapeutics,” Progress in Molecular Biology and Translational Science, vol. 144, pp. 437–484, 2016. View at Publisher · View at Google Scholar
  • Mamoru Tanaka, Hirotada Nishie, Shigenobu Yano, Shugo Suzuki, Noriyuki Hayashi, Takaya Shimura, Tsutomu Mizoshita, Yoshinori Mori, Eiji Kubota, Satoshi Tanida, Satoru Takahashi, Takashi Joh, Hiromi Kataoka, Takuya Sawada, Haruo Akashi, Masahiro Inoue, and Yusuke Inagaki, “Immunogenic cell death due to a new photodynamic therapy (PDT) with glycoconjugated chlorin (G-chlorin),” Oncotarget, vol. 7, no. 30, pp. 47242–47251, 2016. View at Publisher · View at Google Scholar
  • Daria Sollazzo, Dorian Forte, Nicola Polverelli, Margherita Perricone, Marco Romano, Simona Luatti, Nicola Vianelli, Michele Cavo, Francesca Palandri, and Lucia Catani, “Circulating Calreticulin Is Increased in Myelofibrosis: Correlation with Interleukin-6 Plasma Levels, Bone Marrow Fibrosis, and Splenomegaly,” Mediators of Inflammation, vol. 2016, pp. 1–7, 2016. View at Publisher · View at Google Scholar
  • Lan Yi, Jie Yin, Dexin Ding, Nan Hu, Jing Sun, Hongxiang Mu, and Keren Dai, “Up-regulation of calreticulin in mouse liver tissues after long-term irradiation with low-dose-rate gamma rays,” PLoS ONE, vol. 12, no. 9, 2017. View at Publisher · View at Google Scholar
  • Wen-Chin Weng, Kuan-Hung Lin, Pei-Yi Wu, Ya-Hsuan Ho, Yen-Lin Liu, Bo-Jeng Wang, Chien-Chin Chen, Yueh-Chien Lin, Yung-Feng Liao, Wang-Tso Lee, Wen-Ming Hsu, and Hsinyu Lee, “VEGF expression correlates with neuronal differentiation and predicts a favorable prognosis in patients with neuroblastoma,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • David R Spiciarich, Rosalie Nolley, Sophia L Maund, Sean C Purcell, Jason Herschel, Anthony T Iavarone, Donna M Peehl, and Carolyn R Bertozzi, “Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics.,” Angewandte Chemie (International ed. in English), vol. 56, no. 31, pp. 8992–8997, 2017. View at Publisher · View at Google Scholar
  • Anna Rita Migliaccio, and Vladimir N. Uversky, “ Dissecting physical structure of calreticulin, an intrinsically disordered Ca 2+ -buffering chaperone from endoplasmic reticulum ,” Journal of Biomolecular Structure and Dynamics, pp. 1–20, 2017. View at Publisher · View at Google Scholar
  • Kárita C. F. Lidani, Iara J. de Messias-Reason, Lorena Bavia, and Altair R. Ambrosio, “The Complement System: A Prey of Trypanosoma cruzi,” Frontiers in Microbiology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Pin Guan, Wentao Cai, Huapeng Yu, Zhiyong Wu, Juan Chen, Wei Li, Jie Wu, and Guangqiu Feng, “Cigarette smoke extract promotes proliferation of airway smooth muscle cells through suppressing C/EBP-α expression,” Experimental and Therapeutic Medicine, vol. 13, no. 4, pp. 1408–1414, 2017. View at Publisher · View at Google Scholar
  • Carolina Andrea Vera, Lorena Oróstica, Fernando Gabler, Arturo Ferreira, Alberto Selman, Margarita Vega, and Carmen Aurora Romero, “The nerve growth factor alters calreticulin translocation from the endoplasmic reticulum to the cell surface and its signalling pathway in epithelial ovarian cancer cells,” International Journal of Oncology, vol. 50, no. 4, pp. 1261–1270, 2017. View at Publisher · View at Google Scholar
  • Yanyan Jiang, Sandy Wong, Fan Chen, Ted Chang, Hongxu Lu, and Martina H. Stenzel, “Influencing Selectivity to Cancer Cells with Mixed Nanoparticles Prepared from Albumin–Polymer Conjugates and Block Copolymers,” Bioconjugate Chemistry, vol. 28, no. 4, pp. 979–985, 2017. View at Publisher · View at Google Scholar
  • Jie He, Hui Tan, You Hua Wu, Hao Bin Hu, Hui Ling, Xiao Hong Ai, Hao Jiang, Qi Su, Lan Yi, Fang Liu, Xiaoxia Ji, and Xi Zeng, “Identification of potential targets for differentiation in human leukemia cells induced by diallyl disulfide,” International Journal of Oncology, vol. 50, no. 2, pp. 697–707, 2017. View at Publisher · View at Google Scholar
  • Wanlapa Chaibangyang, Amornrat Geadkaew-Krenc, Suksiri Vichasri-Grams, Smarn Tesana, and Rudi Grams, “Molecular and Biochemical Characterization of Opisthorchis viverrini Calreticulin,” The Korean Journal of Parasitology, vol. 55, no. 6, pp. 643–652, 2017. View at Publisher · View at Google Scholar
  • Sheng Zhao, Xiaoming Liu, Yaowei Xu, Xun Li, Wenke Yang, Yanyan Lin, Lili Zhao, Yi Xie, Shuo Li, Wenbo Meng, Xiaodong Xie, Gang Su, Ping Yue, Bing Bai, Jinduo Zhang, Yongjiang Ba, and Zhiwen Luo, “Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics,” Technology in Cancer Research and Treatment, vol. 16, no. 6, pp. 1092–1101, 2017. View at Publisher · View at Google Scholar
  • Oliver Kepp, Jonathan Pol, Laurence Zitvogel, and Guido Kroemer, “Immunogenic Stress and Death of Cancer Cells in Natural and Therapy-Induced Immunosurveillance,” Oncoimmunology, pp. 215–229, 2017. View at Publisher · View at Google Scholar
  • Saori Toujima, Sakiko Nanjo, Sawako Minami, Yoshito Ihara, Madoka Yamamoto, Midori Ikezaki, Naoyuki Iwahashi, Mika Mizoguchi, and Kazuhiko Ino, “Calreticulin is involved in invasion of human extravillous trophoblasts through functional regulation of integrin β1,” Endocrinology, vol. 158, no. 11, pp. 3874–3889, 2017. View at Publisher · View at Google Scholar
  • Myriam P. Hoyeck, Hanane Hadj-Moussa, and Kenneth B. Storey, “ The role of MEF2 transcription factors in dehydration and anoxia survival in Rana sylvatica skeletal muscle ,” PeerJ, vol. 5, pp. e4014, 2017. View at Publisher · View at Google Scholar
  • Weiwei Sheng, Chuanping Chen, Ming Dong, Guosen Wang, Jianping Zhou, He Song, Yang Li, Jian Zhang, and Shuangning Ding, “Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway.,” Cell death & disease, vol. 8, no. 10, 2017. View at Publisher · View at Google Scholar
  • Hongxiang Mu, Jing Sun, Keren Dai, and Lan Yi, “Calreticulin: A potential anti-cancer therapeutic target,” Pharmazie, vol. 72, no. 9, pp. 503–510, 2017. View at Publisher · View at Google Scholar
  • Bin Wang, Wenguo Jiang, Jia Mi, Tingting Men, He Li, Gangming Feng, Fang Liu, Jianke Yang, Jonas Bergquist, Geng Tian, Yuan Zhang, Xingyue Jiang, Chunhua Yang, Xiaodan Wei, and Dong Yan, “Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor B signaling pathway,” Oncotarget, vol. 8, no. 13, pp. 22059–22075, 2017. View at Publisher · View at Google Scholar
  • Yigui Tang, Changgen Shi, Zhiyuan Wu, Ni Fan, Xiao Xu, Zhihua Kang, Xinju Zhang, Weizhe Ma, and Ming Guan, “ A triplex probe-based TaqMan qPCR assay for Calreticulin type I and II mutation detection ,” Hematology, pp. 1–6, 2018. View at Publisher · View at Google Scholar
  • Yueh-Chien Lin, Chien-Chin Chen, Wei-Min Chen, Kuan-Ying Lu, Tang-Long Shen, Yeong-Chin Jou, Cheng-Huang Shen, Norihiko Ohbayashi, Yasunori Kanaho, Yuan-Li Huang, and Hsinyu Lee, “LPA 1/3 signaling mediates tumor lymphangiogenesis through promoting CRT expression in prostate cancer,” Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2018. View at Publisher · View at Google Scholar
  • Eduardo Cruz-Ramos, Antonio Sandoval-Hernández, and Angeles C. Tecalco-Cruz, “Differential expression and molecular interactions of chromosome region maintenance 1 and calreticulin exportins in breast cancer cells,” The Journal of Steroid Biochemistry and Molecular Biology, 2018. View at Publisher · View at Google Scholar
  • Yuan Yao, Yao Zhang, and Xiaoying Fan, “Calreticulin promotes proliferation and extracellular matrix expression through Notch pathway in cardiac fibroblasts,” Advances in Clinical and Experimental Medicine, vol. 27, no. 7, pp. 887–892, 2018. View at Publisher · View at Google Scholar
  • Giorgio Arrigoni, Michelangelo Aloisio, Giuseppe Ricci, Federica Scrimin, Blendi Ura, and Lorenzo Monasta, “Dysregulated chaperones associated with cell proliferation and negative apoptosis regulation in the uterine leiomyoma,” Oncology Letters, vol. 15, no. 5, pp. 8005–8010, 2018. View at Publisher · View at Google Scholar
  • Jia Wei, Peter Stone, Lai-Ming Ching, Wei-Tzu Cheng, Qi Chen, Victoria Rutten, Lawrence W. Chamley, and Mancy Tong, “Phagocytosis of Extracellular Vesicles Extruded From the Placenta by Ovarian Cancer Cells Inhibits Growth of the Cancer Cells,” International Journal of Gynecological Cancer, vol. 28, no. 3, pp. 545–552, 2018. View at Publisher · View at Google Scholar
  • Tapasi Das, Chandraday Prodhan, Santanu Patsa, Jay Gopal Ray, and Keya Chaudhuri, “Identification of over expressed proteins in oral submucous fibrosis by proteomic analysis,” Journal of Cellular Biochemistry, 2018. View at Publisher · View at Google Scholar
  • Mohan Nair, Juan Romero, Aria Mahtabfar, Ahmed Meleis, Ramsey Foty, and Siobhan Corbett, “Dexamethasone-Mediated Upregulation of Calreticulin Inhibits Primary Human Glioblastoma Dispersal Ex Vivo,” International Journal of Molecular Sciences, vol. 19, no. 2, pp. 572, 2018. View at Publisher · View at Google Scholar
  • Juliette Humeau, Sarah Lévesque, Guido Kroemer, and Jonathan G. Pol, “Gold Standard Assessment of Immunogenic Cell Death in Oncological Mouse Models,” Cancer Immunosurveillance, vol. 1884, pp. 297–315, 2018. View at Publisher · View at Google Scholar
  • Patompong Khaw-on, Wilart Pompimon, and Ratana Banjerdpongchai, “Apoptosis Induction via ATM Phosphorylation, Cell Cycle Arrest, and ER Stress by Goniothalamin and Chemodrugs Combined Effects on Breast Cancer-Derived MDA-MB-231 Cells,” BioMed Research International, vol. 2018, pp. 1–15, 2018. View at Publisher · View at Google Scholar
  • Jitka Fucikova, Lenka Kasikova, Iva Truxova, Jan Laco, Petr Skapa, Ales Ryska, and Radek Spisek, “Relevance of the chaperone-like protein calreticulin for the biological behavior and clinical outcome of cancer,” Immunology Letters, vol. 193, pp. 25–34, 2018. View at Publisher · View at Google Scholar
  • Ruchi Jain, Uchenna Watson, Lakshmi Vasudevan, and Deepak K. Saini, “ERK Activation Pathways Downstream of GPCRs,” 2018. View at Publisher · View at Google Scholar
  • Hakan Kulacoglu, and Ferdinand Köckerling, “Hernia and Cancer: The Points Where the Roads Intersect,” Frontiers in Surgery, vol. 6, 2019. View at Publisher · View at Google Scholar