Effect of Fe₃O₄ Nanoparticles on Skin Tumor Cells and Dermal Fibroblasts

Figure 3

(a) Cell viability of SCL-1 tumor cells. Cells (SCL-1) were incubated with Fe₃O₄ nanoparticles. The percentage of living cells after 72 h was measured. . Ct: control (untreated). (b) Involvement of Fe₃O₄ nanoparticles in tumor invasion. Conditioned media of HDF (), myofibroblasts (), and fibroblasts incubated with 50 μM or 350 μM Fe₃O₄ nanoparticles and rTGFβ1 () were used to check the invasive capacity of tumor cells. The data represent the mean ± s.e.m. . (c) Direct effect of Fe₃O₄ nanoparticles on tumor cells. SCL-1 tumor cells were untreated or incubated with 350 μm Fe₃O₄ nanoparticles for 24 h. The invasion assay was performed with conditioned media of HDF () and myofibroblasts (). The data represent the mean ± s.e.m. . < 0.05 versus (Student’s -test). CM: conditioned medium.

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