CEUS guided percutaneous biopsy of lung tuberculosis. (a) Gray-scale ultrasound detected a hypoechoic and homogeneous lesion in the upper lobe of left lung. (b) CDFI detected no color flow inside the lesion. (c) After injection of SonoVue, the enhancement began approximately at the peripheral region from 11 sec (arrow). (d) After CEUS, 16-gauge core needle percutaneous biopsies were performed under the real-time guidance of ultrasound in the active area (the lesion’s peripheral region). (e) Biopsy histopathological diagnosis revealed it was a lesion of lung tuberculosis, with neutrophils, lymphocytes, and mononuclear cell infiltration.