Gene Profiling of Bone around Orthodontic Mini-Implants by RNA-Sequencing Analysis
Table 1
Main genes that were up- or downregulated based on the gene ontology (GO) analysis at week 1 compared with the levels of expression in the control.
Upregulated genes
Downregulated genes
GO category
Numbers of genes
value
GO category
Numbers of genes
value
Cellular component
Basement membrane
14
<0.0001
Apical plasma membrane
15
<0.0001
Extracellular matrix
38
<0.0001
Glutamate-cysteine ligase complex
2
<0.0001
Extracellular region
53
<0.0001
Hemoglobin complex
2
<0.0001
Extracellular space
47
<0.0001
Intermediate filament
12
<0.0001
Proteinaceous extracellular matrix
17
0.0001
Keratin filament
8
<0.0001
Biological process
Cartilage morphogenesis
3
<0.0001
Adhesion to symbiont
2
<0.0001
Collagen fibril organization
9
<0.0001
Cellular aldehyde metabolic process
3
<0.0001
DNA replication
13
<0.0001
Cilium movement
4
0.0003
DNA replication initiation
5
<0.0001
Desmosome organization
2
<0.0001
DNA unwinding involved in DNA replication
4
<0.0001
Fucose metabolic process
2
<0.0001
Extracellular fibril organization
3
0.0003
Glutathione metabolic process
9
<0.0001
Extracellular matrix organization
11
0.0003
Male sex differentiation
2
<0.0001
Regulation of cell growth
7
<0.0001
Neutrophil aggregation
2
<0.0001
Oxidation-reduction process
49
<0.0001
Positive regulation of cation channel activity
2
<0.0001
Protein homotetramerization
8
<0.0001
Regulation of cell death
3
0.0003
Response to metal ion
2
<0.0001
Molecular function
Calcium ion binding
42
0.0002
Aldehyde dehydrogenase (NAD) activity
3
<0.0001
DNA helicase activity
6
<0.0001
Aldehyde dehydrogenase [NAD(P)+] activity
2
<0.0001
Extracellular matrix binding
7
<0.0001
Alpha-L-fucosidase activity
2
<0.0001
Extracellular matrix structural constituent
7
<0.0001
Flavin adenine dinucleotide binding
12
<0.0001
Heparin binding
11
<0.0001
Glutamate-cysteine ligase activity
2
<0.0001
Insulin-like growth factor binding
7
<0.0001
Oxidoreductase activity
44
<0.0001
Platelet-derived growth factor binding
5
<0.0001
Oxidoreductase activity, acting on CH-OH group of donors
5
<0.0001
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
5
0.0003
Structural molecule activity
16
0.0001
Superoxide dismutase activity
3
0.0003
UDP-N-acetylmuramate dehydrogenase activity
4
<0.0001
The values were compared according to fold change.
