Splicing Regulation: A Molecular Device to Enhance Cancer Cell Adaptation

Figure 3

Regulation of chemoresistance via alternative messenger RNA splicing. Chemotherapy can affect the subnuclear distribution of SAM68 (left panel) and the expression of SRSF1 (right panel), thus modulating AS of cancer-related variants (CD44v and MNK2b, resp.) and contributing to chemoresistance. Green boxes indicate constitutive exons; red, yellow, and violet boxes indicate variable exons.