The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer

Table 3

Univariate and multivariate analysis of risk factors of lymph node metastasis in gastric cancer.

	Without LNM	With LNM	value
	(%)	(%)	Univariate analysis	Multivariate analysis
Age (y/o)			0.758
<65	9 (39.1)	7 (30.4)
≧65	14 (60.9)	16 (69.6)
Gender			0.130
M/F	17/6	11/12
Tumor size (cm)			0.236
<5	15 (65.2)	10 (43.5)
≧5	8 (34.8)	13 (56.5)
Tumor location			0.767
Upper third stomach	5 (21.7)	3 (13.6)
Middle third stomach	9 (39.1)	10 (45.5)
Lower third stomach	9 (39.1)	9 (40.9)
Lauren’s classification			0.071
Intestinal type	17 (52.6)	10 (43.5)
Diffuse type	6 (47.4)	13 (56.5)
Cell differentiation			0.236
Poor	8 (34.8)	13 (45.5)
Moderate/well	15 (65.2)	10 (56.6)
Stromal reaction type			<0.001	<0.001
Medullary	7 (30.4)	0
Intermediate	16 (69.6)	17 (73.9)
Scirrhous	0	6 (26.1)
Lymphovascular invasion			<0.001	<0.001
Absence	18 (78.3)	5 (21.7)
Presence	5 (21.7)	18 (78.3)
Pathological T categories			<0.001	<0.001
T1	11 (47.8)	1 (4.3)
T2	8 (34.8)	4 (17.4)
T3	4 (17.4)	15 (65.2)
T4	0	3 (13)
Pathological TNM stage			<0.001	<0.001
I	19 (82.6)	0
II	4 (17.4)	10 (43.5)
III	0	7 (30.4)
IV	0	6 (26.1)
Expression of miR-1207-5p			<0.001	<0.001
No change	7 (30.4)	20 (87)
Downregulation	1 (4.3)	1 (4.3)
Upregulation	15 (65.2)	2 (8.7)

LNM: lymph node metastasis.