Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins

Figure 7

Colon tissue from T. crassiceps-infected mice and uninfected mice displays different levels of AAM-associated transcripts. (a) Colon tissue was collected at the end of the experiments, and transcript levels of GAPDH, Arginase 1, Fizz1, Ym1, and iNOS were analyzed by RT-PCR. (b) Densitometry of Arg 1, Fizz1, Ym1, and iNOS. (c) Histology with Mason stain for the identification of collagen deposition as a sign of fibrosis. T. crassiceps infection does not induce fibrosis during colitis (collagen in dark blue). Magnification = 10x.

(a)

(b)

(c)