Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins

Figure 8

F4/80⁺MR⁺-sorted peritoneal macrophages from T. crassiceps-infected mice transferred intraperitoneally into naïve mice inhibit the development of colitis. (a) F4/80⁺MR⁺ peritoneal macrophages sorted from T. crassiceps-infected mice inhibit CD4 and CD8 T cell proliferation (data not shown for CD8). In contrast, sorted F4/80⁺MR⁻ macrophages from the same mice do not suppress CD4 cell proliferation. (b) Colon length of mice with ulcerative colitis that received F4/80⁺MR⁺ and F4/80⁺MR⁻ cells. (c) Infiltration of inflammation. (d) Histology of the effect of F4/80⁺MR⁺ adoptive transfer during colitis: magnification is 20x for all the slides shown. Bars represent the mean ± SD from three slides per mouse. , , mice per group. All data are representative of two independent experiments.

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