Protective and Curative Effects of the Sea Cucumber Holothuria atra Extract against DMBA-Induced Hepatorenal Diseases in Rats

Table 1

Modulatory influence of Holothuria atra extract (HaE) on alanine (ALAT) and aspartate (ASAT) aminotransaminase activities of 7,12-dimethylbenz[a]anthracene (DMBA) treated rats.

Treatment	Groups		ALAT; (U/mL)	ASAT; (U/mL)
Pretreatment	Control		134.25 ± 5.55^ab	175.05 ± 6.26^a
	7 days	DMBA	159.50 ± 9.00^cd	217.35 ± 6.28^de
		HaE	151.85 ± 4.40^bcd	206.75 ± 5.36^bcd
	14 days	DMBA	177.75 ± 5.93^e	229.60 ± 3.38^d
		HaE	141.45 ± 5.12^ab	189.75 ± 3.48^ab
Posttreatment	Control		133.85 ± 7.10^a	175.85 ± 6.25^a
	7 days	DMBA	165.65 ± 4.49^de	209.60 ± 7.28^cd
		HaE	145.70 ± 2.75^abc	195.4 ± 10.73^bc
	14 days	DMBA	178.75 ± 5.33^e	229.75 ± 0.93^d
		HaE	138.70 ± 3.47^ab	194.60 ± 5.39^bc

Values are given as mean ± SEM for 6 rats in each group.
Each value not sharing a common letter superscript is significantly different ().