Research Article
Preparation, Optimization, and Screening of the Effect of Processing Variables on Agar Nanospheres Loaded with Bupropion HCl by a D-Optimal Design
Table 1
Design of the experiment according to a D-optimal design for formulating agar nanospheres loaded with bupropion HCl.
| | Formulation | CaCl2 (%) | Homogenizer speed (rpm) | Agar (%) | HPCD (%) | Particle size (nm) | Zeta potential (mV) | Loading efficiency (%) | RE300 (%) | PdI |
| | C10S8000A2H1 | 10 | 8000 | 2 | 1 | 534.5 ± 18.6 | −31.5 | 34.7 ± 0.3 | 90 ± 3 | 0.22 | | C6S10000A2H0.5 | 6 | 10000 | 2 | 0.5 | 716.2 ± 163.7 | −32.8 | 31.4 ± 1.1 | 63 ± 6 | 0.62 | | C10S8000A2H1 | 10 | 8000 | 2 | 1 | 525.9 ± 63.7 | −30.2 | 41.5 ± 1.2 | 79 ± 4 | 0.54 | | C10S12000A1H0 | 10 | 12000 | 1 | 0 | 613.4 ± 146.1 | −27.2 | 29.4 ± 1.8 | 81 ± 10 | 0.56 | | C2S8000A2H0 | 2 | 8000 | 2 | 0 | 406.5 ± 79.6 | −31.7 | 44.6 ± 2.7 | 70 ± 7 | 0.53 | | C6S10000A1.5H0 | 6 | 10000 | 1.5 | 0 | 503.9 ± 181.3 | −31.0 | 35.4 ± 2.2 | 86 ± 8 | 0.45 | | C2S10000A2H1 | 2 | 10000 | 2 | 1 | 504.5 ± 114.8 | −28.0 | 38.9 ± 0.9 | 80 ± 8 | 0.99 | | C6S8000A1.5H0.5 | 6 | 8000 | 1.5 | 0.5 | 807.2 ± 86 | −25.9 | 39.5 ± 1.5 | 84 ± 5 | 0.51 | | C2S12000A1H1 | 2 | 12000 | 1 | 1 | 491.3 ± 29.9 | −22.9 | 18.9 ± 2.0 | 84 ± 26 | 0.38 | | C10S10000A1.5H0.5 | 10 | 10000 | 1.5 | 0.5 | 492.3 ± 54.9 | −25.4 | 34.9 ± 2.3 | 84 ± 17 | 0.9 | | C10S12000A1H0 | 10 | 12000 | 1 | 0 | 310.3 ± 10.4 | −21.7 | 27.7 ± 1.0 | 77 ± 7 | 0.33 | | C2S8000A1H1 | 2 | 8000 | 1 | 1 | 659.1 ± 80.2 | −29.9 | 20.8 ± 0.7 | 86 ± 9 | 0.21 | | C6S8000A1H0 | 6 | 8000 | 1 | 0 | 670.1 ± 159.5 | −27.9 | 18.9 ± 0.4 | 72 ± 8 | 0.73 | | C2S12000A2H0 | 2 | 12000 | 2 | 0 | 519.7 ± 74.3 | −34.2 | 43.6 ± 0.3 | 78 ± 4 | 0.48 | | C2S8000A2H0 | 2 | 8000 | 2 | 0 | 713.4 ± 97.3 | −35.2 | 40.0 ± 1.0 | 78 ± 3 | 0.42 | | C10S12000A2H1 | 10 | 12000 | 2 | 1 | 494.5 ± 19.3 | −29.8 | 36.3 ± 0.3 | 91 ± 6 | 0.52 | | C10S8000A1H0.5 | 10 | 8000 | 1 | 0.5 | 723.2 ± 304.7 | −24.6 | 32.1 ± 0.5 | 87 ± 2 | 0.61 | | C6S10000A1.5H1 | 6 | 10000 | 1.5 | 1 | 455.3 ± 153.3 | −31.3 | 37.2 ± 0.6 | 86 ± 3 | 0.69 | | C10S10000A2H0 | 10 | 10000 | 2 | 0 | 453.2 ± 19 | −30.0 | 44.3 ± 0.9 | 78 ± 2 | 0.25 | | C10S8000A1.5H0 | 10 | 8000 | 1.5 | 0 | 619.9 ± 132.2 | −28.0 | 45.6 ± 2.2 | 87 ± 10 | 0.63 | | C4S11000A1.25H0.5 | 4 | 11000 | 1.25 | 0.5 | 443.4 ± 22.9 | −34.7 | 31.7 ± 0.7 | 85 ± 4 | 0.72 | | C10S12000A2H1 | 10 | 12000 | 2 | 1 | 674.1 ± 79.1 | −31.7 | 30.0 ± 1.1 | 87 ± 5 | 0.47 | | C10S10000A1H1 | 10 | 10000 | 1 | 1 | 357.3 ± 7.9 | −29.0 | 26.6 ± 1.3 | 65 ± 4 | 0.58 | | C2S12000A2H0 | 2 | 12000 | 2 | 0 | 641.7 ± 32.0 | −27.3 | 44.1 ± 2.4 | 67 ± 5 | 0.51 | | C2S10000A1H0 | 2 | 10000 | 1 | 0 | 776.6 ± 50.1 | −37.1 | 36.6 ± 1.1 | 74 ± 4 | 0.54 |
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C: CaCl2, S: speed of homogenizer, A: agar, and H: hydroxyl -cyclodextrin.
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