Preparation, Optimization, and Screening of the Effect of Processing Variables on Agar Nanospheres Loaded with Bupropion HCl by a D-Optimal Design

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left"> </td><td align="center">Particle size (nm)</td><td align="center">Zeta potential (mV)</td><td align="center">Loading efficiency (%)</td><td align="center">RE<sub>300</sub> (%)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left">Predicted</td><td align="center">577.68</td><td align="center">−30.10</td><td align="center">43.5</td><td align="center">69.49</td></tr><tr><td align="left">Real</td><td align="center">587 ± 58</td><td align="center">−30.9</td><td align="center">38.6 ± 1.3</td><td align="center">51 ± 9</td></tr><tr><td align="left">Error percent</td><td align="center">1.61</td><td align="center">2.65</td><td align="center">11.26</td><td align="center">26.6</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Predicted versus real response factors for the optimum formulation (measured in deionized and purified water).

BioMed Research International

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Table 4

Table 4: Preparation, Optimization, and Screening of the Effect of Processing Variables on Agar Nanospheres Loaded with Bupropion HCl by a D-Optimal Design 

Table 4 | Preparation, Optimization, and Screening of the Effect of Processing Variables on Agar Nanospheres Loaded with Bupropion HCl by a D-Optimal Design 