Nonalcoholic Steatohepatitis: A Search for Factual Animal Models

Figure 3

Genetic animal models used for the development of NAFLD/NASH: (a) Zucker rats—the recessive (fa/fa) genotype develops obesity and liver steatosis (at left side), while the dominant (lean) genotype is phenotypically normal (at right side of the picture); (b) Ob/ob mice—the mutant obese (ob/ob) mouse (at left side) may present threefold higher body weight relative to the wild type mouse (at right side of the picture) (The Jackson Laboratory).

(a)

(b)