Review Article

TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation

Figure 2

Structure and sequence analysis of TTBK2. (a) A model structure of the kinase domain of TTBK2 with a bound ATP using the crystal structure of TTBK1 as a template. (b) Top-hit homologous sequences of the noncatalytic domain of TTBK2 identified by protein BLAST. Two separate BLAST searches were performed against two segments: residues 281 to 448 covering the region remained in SCA11 patients (white bars) and residues 489 to 1244 covering the rest of the noncatalytic domain (black bars).