Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015 (2015), Article ID 575474, 6 pages
http://dx.doi.org/10.1155/2015/575474
Research Article

Prophylactic Antiarrhythmic Effect of Anesthetics at Subanesthetic Concentration on Epinephrine-Induced Arrhythmias in Rats after Brain Death

1Department of Anesthesiology, Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan
2Department of Anesthesiology, Sakurabashi-Watanabe Hospital, 2-4-32 Umeda, Kita-ku, Osaka 530-0001, Japan

Received 7 June 2014; Accepted 17 September 2014

Academic Editor: Hideo Inaba

Copyright © 2015 Yuka Miyata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. W. McKeown, R. S. Bonser, and J. A. Kellum, “Management of the heartbeating brain-dead organ donor,” British Journal of Anaesthesia, vol. 108, no. 1, pp. i96–i107, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. J. L. Atlee III and Z. J. Bosnjak, “Mechanisms for cardiac dysrhythmias during anesthesia,” Anesthesiology, vol. 72, no. 2, pp. 347–374, 1990. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Hirata, N. Kanaya, N. Kamada, S. Kimura, and A. Namiki, “Differential effects of propofol and sevoflurane on ischemia-induced ventricular arrhythmias and phosphorylated connexin 43 protein in rats,” Anesthesiology, vol. 110, no. 1, pp. 50–57, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. J. F. Bugge, “Brain death and its implications for management of the potential organ donor,” Acta Anaesthesiologica Scandinavica, vol. 53, no. 10, pp. 1239–1250, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. T. Takamatsu, “Arrhythmogenic substrates in myocardial infarct,” Pathology International, vol. 58, no. 9, pp. 533–543, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. M. Iwasaki, Y. Hayashi, H. Yamanaka, T. Kamibayashi, and T. Mashimo, “Nicorandil preserves myocardial function following brain death in rats by mitochondrial adenosine triphosphate-sensitive potassium channel-dependent mechanism,” European Journal of Cardio-thoracic Surgery, vol. 40, no. 3, pp. 710–714, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. J. Pratschke, M. J. Wilhelm, M. Kusaka, I. Laskowski, and N. L. Tilney, “A model of gradual onset brain death for transplant-associated studies in rats,” Transplantation, vol. 69, no. 3, pp. 427–430, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. R. I. Mazze, S. A. Rice, and J. M. Baden, “Halothane, isoflurane, and enflurane MAC in pregnant and nonpregnant female and male mice and rats,” Anesthesiology, vol. 62, no. 3, pp. 339–341, 1985. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Taheri, M. J. Halsey, J. Liu, E. I. Eger II, D. D. Koblin, and M. J. Laster, “What solvent best represents the site of action of inhaled anesthetics in humans, rats, and dogs?” Anesthesia and Analgesia, vol. 72, no. 5, pp. 627–634, 1991. View at Google Scholar · View at Scopus
  10. F. J. Carmichael, M. W. Crawford, N. Khayyam, and V. Saldivia, “Effect of propofol infusion on splanchnic hemodynamics and liver oxygen consumption in the rat: a dose-response study,” Anesthesiology, vol. 79, no. 5, pp. 1051–1060, 1993. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Takada, K. Sumikawa, T. Kamibayashi et al., “Comparative efficacy of antiarrhythmic agents in preventing halothane-epinephrine arrhythmias in rats,” Anesthesiology, vol. 79, no. 3, pp. 563–570, 1993. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Iwasaki, Y. Hayashi, T. Kamibayashi, A. Yamatodani, and T. Mashimo, “The antiarrhythmic effect of centrally administered rilmenidine involves muscarinic receptors, protein kinase C and mitochondrial signalling pathways,” The British Journal of Pharmacology, vol. 153, no. 8, pp. 1623–1630, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. R. R. Johnston, E. I. Eger II, and C. Wilson, “A comparative interaction of epinephrine with enflurane, isoflurane, and halothane in man,” Anesthesia and Analgesia, vol. 55, no. 5, pp. 709–712, 1976. View at Google Scholar · View at Scopus
  14. Y. Hayashi, K. Sumikawa, C. Tashiro, A. Yamatodani, and I. Yoshiya, “Arrhythmogenic threshold of epinephrine during sevoflurane, enflurane, and isoflurane anesthesia in dogs,” Anesthesiology, vol. 69, no. 1, pp. 145–147, 1988. View at Google Scholar · View at Scopus
  15. T. A. D'Amico, C. H. Meyers, T. C. Koutlas et al., “Desensitization of myocardial β-adrenergic receptors and deterioration of left ventricular function after brain death,” The Journal of Thoracic and Cardiovascular Surgery, vol. 110, no. 3, pp. 746–751, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Ren, P. P. Mehta, and R. J. Ruch, “Inhibition of gap junctional intercellular communication by tumor promoters in connexin43 and connexin32-expressing liver cells: cell specificity and role of protein kinase C,” Carcinogenesis, vol. 19, no. 1, pp. 169–175, 1998. View at Publisher · View at Google Scholar · View at Scopus