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BioMed Research International
Volume 2015 (2015), Article ID 575837, 10 pages
http://dx.doi.org/10.1155/2015/575837
Research Article

Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells into Insulin-Producing Cells: Evidence for Further Maturation In Vivo

1Department of Biotechnology, Urology and Nephrology Center, Mansoura 35516, Egypt
2Department of Nephrology, Urology and Nephrology Center, Mansoura 35516, Egypt
3Department of Pathology, Urology and Nephrology Center, Mansoura 35516, Egypt
4Department of Immunology, Urology and Nephrology Center, Mansoura 35516, Egypt
5Department of Urology, Urology and Nephrology Center, Mansoura 35516, Egypt

Received 5 November 2014; Accepted 11 January 2015

Academic Editor: Aaron W. James

Copyright © 2015 Mahmoud M. Gabr et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Material: In figure (1), the multilineage potentials of HBM-MSCs intoadipocytes, chondrocytes and osteocytes had been provided. The cytoflowmetric characterization of HBM-MSCs is shown in table (1). Table 2 shows the glucose tolerance data of the transplanted animals at different time points. In addition to glucose levels, c-peptide values were also determined. The percentage of insulin-positive cells at end of differentiation and following transplantation are given in table 3. Table 4, demonstrates data of the relative gene expression of relevant pancreatic endocrine genes at end of differentiation as well as following transplantation.

  1. Supplementary Materials