Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells into Insulin-Producing Cells: Evidence for Further Maturation In Vivo

Table 1

Mean blood glucose and serum human insulin, c-peptide, and serum mouse insulin levels in mice transplanted with HBM-MSCs (human bone marrow-derived mesenchymal stem cells).

	Basal	After induction of diabetes	After transplantation
			1 week	2 weeks	4 weeks	12 weeks
Blood glucose (mg/dL)	117.5 ± 14.15	359.5 ± 49.6	121.0 ± 24.2	167.2 ± 32.6	146.67 ± 24.1	103.2 ± 17.6
Serum human insulin (IU/mL)	—	—	29.2 ± 7.57	30.5 ± 6.4	29.64 ± 2.9	32.8 ± 2.86
Serum human c-peptide (ng/mL)	—	—	0.4 ± 0.14	0.33 ± 0.12	0.18 ± 0.39	0.4 ± 0.09
Serum mouse insulin (IU/mL)	3.65 ± 1.8	—	—	0.4 ± 0.089	0.43 ± 0.11	0.34 ± 0.10