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BioMed Research International
Volume 2015, Article ID 583293, 11 pages
http://dx.doi.org/10.1155/2015/583293
Research Article

Decreased Pulmonary Function in School Children in Western Japan after Exposures to Asian Desert Dusts and Its Association with Interleukin-8

1Department of Respiratory Medicine and Rheumatology, Tottori University Hospital, Yonago 683-8504, Japan
2Department of Data Science, Institute of Statistical Mathematics, Tokyo 190-8562, Japan
3Department of Respiratory Medicine and Allergology, Kinki University Faculty of Medicine, Osakasayama 589-8511, Japan
4Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8574, Japan
5Chromosome Engineering Research Center, Tottori University, Tottori 683-8504, Japan
6Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan

Received 2 July 2014; Revised 24 September 2014; Accepted 13 November 2014

Academic Editor: How-Ran Guo

Copyright © 2015 Masanari Watanabe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The objective of the study was to investigate the influence of Asian dust storms (ADS) on pulmonary function of school children and the relationship of this effect with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children from April to May 2012 and in 384 of these children from March to May 2013. The data were analyzed for an association between ADS events and PEF by linear mixed models. Interleukin-8 transcriptional activity was assessed in THP-G8 cells stimulated by airborne particles collected on ADS days. Seven ADS days were identified: April 23 and 24, 2012; March 8 to 10, 2013; and March 19 and 20, 2013. Changes in PEF after ADS exposure were −8.17 L/min (95% confidence interval, −11.40 to −4.93) in 2012 and −1.17 L/min (−4.07 to 1.74) in 2013, and there was a significant difference between 2012 and 2013. Interleukin-8 transcriptional activity was significantly higher in 2012 at -fold compared to in March 8 to 10, 2013, and in March 19 and 20, 2013. The influence of ADS events on pulmonary function of children differs with each ADS event and may be related to interleukin-8 production.