Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: MRI and ¹⁸F-FDG PET Quantitative Analysis Using FreeSurfer

Table 2

MRI relative volume (%) for each region and group.

	AD	HC	MCI
				Global	AD versus HC	AD versus MCI	MCI versus HC
Hippocampus
Mean (SD)	0.574 (0.095)	0.747 (0.062)	0.636 (0.099)	0.00005	0.00003	0.05293	0.0013
Median (min–max)	0.591 [0.34–0.732]	0.764 [0.601–0.82]	0.648 [0401–0.819]
Amygdala
Mean (SD)	0.234 (0.044)	0.276 (0.043)	0.251 (0.058)	0.06152
Median (min–max)	0.234 [0.148–0.337]	0.271 [0.21–0.362]	0.245 [0.145–0.366]
Precuneus
Mean (SD)	1.557 (0.116)	1.532 (0.105)	1.47 (0.246)	0.85693
Median (min–max)	1.511 [1.366–1.77]	1.522 [1.377–1.675]	1.539 [0.816–1.755]
Caudal anterior cingulate
Mean (SD)	0.323 (0.054)	0.333 (0.054)	0.319 (0.072)	0.86231
Median (min–max)	0.322 [0.207–0.442]	0.341 [0.252–0.416]	0.316 [0.165–0.447]
Rostral anterior cingulate
Mean (SD)	0.415 (0.06)	0.378 (0.068)	0.379 (0.089)	0.37687
Median (min–max)	0.414 [0.296–0.511]	0.386 [0.248–0.477]	0.406 [0.126–0.481]
Isthmus cingulate
Mean (SD)	0.43 (0.035)	0.401 (0.048)	0.398 (0.065)	0.17212
Median (min–max)	0.425 [0.364–0.488]	0.399 [0.331–0.503]	0.401 [0.256–0.488]
Posterior cingulate
Mean (SD)	0.509 (0.042)	0.543 (0.025)	0.503 (0.095)	0.04422	0.05841	0.97289	0.05841
Median (min–max)	0.513 [0.443–0.579]	0.542 [0.504–0.589]	0.509 [0.268–0.68]

AD: Alzheimer’s disease; MCI: mild cognitive impairment.
Regional volumes are means of both right and left structures.