Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: MRI and 18F-FDG PET Quantitative Analysis Using FreeSurfer
Table 3
18F-FDG cerebral metabolic rate of glucose (SUVr) for each region and group.
AD
HC
MCI
Global
AD versus HC
AD versus MCI
MCI versus HC
Hippocampus
Mean (SD)
0.69 (0.10)
0.84 (0.10)
0.75 (0.13)
0.00227
0.00119
0.19004
0.06322
Median (min–max)
0.71 [0.40–0.83]
0.82 [0.71–1.11]
0.75 [0.45–1.02]
Amygdala
Mean (SD)
0.64 (0.11)
0.77 (0.17)
0.71 (0.19)
0.05145
Median (min–max)
0.67 [0.35–0.77]
0.71 [0.66–1.31]
0.69 [0.39–1.33]
Precuneus
Mean (SD)
1.02 (0.09)
1.26 (0.16)
1.09 (0.10)
0.00002
0.00004
0.04928
0.00172
Median (min–max)
1.02 [0.84–1.16]
1.21 [1.05–1.67]
1.11 [0.89–1.25]
Anterior cingulate
Mean (SD)
0.91 (0.10)
1.06 (0.10)
0.96 (0.25)
0.00093
0.00129
0.86309
0.00385
Median (min–max)
0.92 [0.65–1.07]
1.03 [0.93–1.27]
0.91 [0.64–1.81]
Posterior cingulate
Mean (SD)
0.96 (0.11)
1.22 (0.13)
1.06 (0.17)
0.00002
0.00005
0.04939
0.00112
Median (min–max)
0.98 [0.72–1.16]
1.19 [1.05–1.55]
1.07 [0.77–1.57]
SUVr represents regional maximal PET intensity to cerebellum ratio. AD: Alzheimer’s disease; MCI: mild cognitive impairment. Anterior cingulate stands for caudal anterior cingulate, rostral anterior cingulate, and isthmus cingulate cortex.
