Calcium Channel Expression and Applicability as Targeted Therapies in Melanoma

Table 1

Expression and physiological role of calcium channels in melanoma.

Ca^2+ channel	Expression in melanoma cells relative to melanocytes	Effects	References
TRPM1	Very low/undetectable	Proapoptotic; Reduced metastatic potential; Reduced migration and invasion	[16, 26, 38–42]
TPRM8	Increased	Favored tumor progression	[17, 43]
TRPM2	Increased	Increased proliferation by overexpression	[38, 44]
TRPM7	Increased	Favored metastasis and invasion	[38, 45]
SOCE	Increased	Prosurvival; Increased proliferation	[46–48]
T-type	Increased	Increased proliferation; Macroautophagy blocked by pharmacological inhibition/gene silencing	[36, 49]