In Vivo MicroCT Monitoring of Osteomyelitis in a Rat Model

Figure 4

(a) Evolution of bone-implant contact (BIC) in ROI1 and bone fraction (BV/TV) in ROI2 evaluated by in vivo microCT. The evolution was significantly different between control and infected animals, with sterile control screws leading to rapid integration and bacteria colonized screws leading to rapid bone loss. (b) Bone formation and bone resorption evaluated by comparing subsequent in vivo microCT scans. Infected animals suffer a significantly reduced bone formation between days 3 and 6 post-op and a significantly increased bone resorption until day 9 post-op. (c) Evolution of stiffness and failure load evaluated by microFE simulations. (, ).

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