Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children

Figure 2

Blood and urine IP-10 levels are significantly increased in children with “active TB” compared to healthy adult donors (HAD). (a-b) Blood IP-10 levels were significantly increased in the children with a diagnosis of “active TB” and “respiratory diseases” compared to HAD, independent of HIV status. (c-d) Urine IP-10 levels were increased in the children diagnosed with “active TB” compared to the other two groups (HAD and “respiratory diseases”). IP-10 ELISA was performed in plasma and urine, and urine IP-10 was normalized with the creatinuria levels. The horizontal lines represent the median; statistical analysis was performed using the Mann-Whitney test with Bonferroni correction and value was considered significant if <0.016. IP-10: IFN- inducible protein 10; HAD: healthy adult donors; TB: tuberculosis; HIV: Human Immunodeficiency Virus.

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