Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children

Table 4

Sensitivity and specificity results of IP-10-based tests, QFT-IT, and TST evaluated in children with a diagnosis of “active TB” versus “respiratory diseases.”

	Test	Cut-off	Sensitivity; %	Sensitivity; %; excluding indeterminate results of the QFT	Specificity; %	Specificity; %; excluding indeterminate results of the QFT
HIV status
HIV-uninfected	IP-10 blood (pg/mL)	209.1	79	NA	53	NA
	IP-10 urine (mg/g)	0.0000032	53	NA	66	NA
	QFT-IT		53	56	83	88
	TST		61	NA	82	NA
HIV-infected	IP-10 blood (pg/mL)	209.1	100	NA	17	NA
	IP-10 urine (mg/g)	0.0000032	54	NA	61	NA
	QFT-IT		17	17	82	100
	TST		23	NA	94	NA

TB: tuberculosis; HIV: Human Immunodeficiency Virus; QFT-IT: QuantiFERON TB-Gold In-Tube; TST: tuberculin skin test; IP-10: interferon-γ-inducible protein 10.