In Vitro and In Vivo Response to Low-Modulus PMMA-Based Bone Cement
Viability of Saos-2 cultured for 1 and 3 days in 1, 6, 12, and 24 h extracts prepared with OP, OP + LA, and OP + CO. (a) Undiluted extracts; (b) 4-fold diluted extracts; (c) 10-fold diluted extracts. For each extract time, and indicate statistical differences () between each sample and OP at 1 day and 3 days, respectively. The error bars represent the standard deviation of the mean. Four replicates per sample were included in the assay. C− refers to negative control (fresh media) and C+ refers to positive control (0.1% triton).