Study of Osteoarthritis Treatment with Anti-Inflammatory Drugs: Cyclooxygenase-2 Inhibitor and Steroids

Figure 3

Protein production assays for MMP-1 and PGE2 in vitro after treatment with TNF-α with or without additional drugs. MMP-1 and PGE2 after treatment with TNF-α (5 ng/mL) with or without drug treatment. (a) shows that TNF-α induced MMP-1 production (compare columns 1 and 2). All drug/TNF-α combinations result in less MMP-1 production, with celecoxib reducing production of MMP-1 most dramatically. (b) shows that TNF-α alone induces PGE2 production. All drugs significantly reduce PGE-2 production, celecoxib being the most effective. The dotted line represents PGE-2 production with no TNF-α and no drug treatment.

(a)

(b)