Recent Advances in Molecular Magnetic Resonance Imaging of Liver Fibrosis

Table 1

Studies that have assessed molecular MRI of liver fibrosis.

Study/year	Targeted molecules	Targeting probes	Animal model	MR effect	Significance
Polasek et al., 2012 [40]	Type I collagen	EP-3533	The rat DEN model & the CCl4 mouse model	Shortening the T1 relaxation time	Identifies fibrotic tissue in animal models of liver fibrosis
Fuchs et al., 2013 [41]	Type I collagen	EP-3533	The CCl4 mouse model	Shortening the T1 relaxation time	Diagnoses and stage sliver fibrosis in an animal model
Chow et al., 2013 [42]	Fibrin-fibronectin	CLT1-peptide-targeted nanoglobular contrast agent; (CLT1(Gd-DOTA))	The CCl4 mouse model	Shortening the T1 relaxation time	Detected and stage sliver fibrosis by probing the accumulation of fibronectin
Ehling et al., 2013 [43]	Elastin	ESMA	The CCl4 mouse model	Shortening the T1 relaxation time	Elastin-based molecular MRI may be suitable for noninvasive monitoring of ECM remodeling during liver fibrosis
Wang et al., 2011 [44]	-Integrin	c(RGDyC)-USPIO	The CCl4 mouse model	Shortening the T2 relaxation time	Targets HSC imaging with c(RGDyC)-USPIO