The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism

Table 1

The effect of Nrf2 activation/deficiency on hepatic lipid accumulation in C57BL/6 mice.

Gender	Age; (weeks)	Hepatic lipid accumulation	Expression of FA synthesis genes	Reference
(a) Standard diet
Male	8	Increased steatosis in Nrf2^−/−. No difference in TGs	Higher in Nrf2^−/−	[18]
Male	9	Reduced by Nrf2 activation	Reduced by Nrf2 activation	[19]
Male	10	Not reported	Higher in Nrf2^−/−	[20]
Male	12	No difference in TGs	No difference	[21]
Male	19	Tendency for increased TGs in Nrf2^−/−	Tendency for higher levels in Nrf2^−/−	[22]
Male	25	No difference in TGs	No difference	[23]
(b) High-fat diet
Male	12	Increased FFAs. No difference in TGs	Higher in Nrf2^−/−	[21]
Male	19	Tendency for increased TGs in Nrf2^−/−	No difference	[22]
Female	21	Reduced lipid content by Nrf2 activation	Reduced by Nrf2 activation	[24]
Male	25	No difference in TGs	No difference	[23]
Male	26	Reduced total lipid and TGs in Nrf2^−/−	Lower in Nrf2^−/−	[25]

FFA, free fatty acids; TG, triglyceride.