Diagnosis of Neisseria gonorrhoeae Using Molecular Beacon

Table 2

Comparison of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), likelihood ratios (LR), and accuracy of different methods calculated with 95% confidence intervals (CI).

Result of samples; ()	PCR		Beacon		Roche AMPLICOR MWP kit		Rmp
	Positive	Negative	Positive	Negative	Positive	Negative	Positive	Negative
NG positive	163	5	165	3	165	3	164	4
NG negative	2	242	1	243	2	242	2	242
Sensitivity (95% CI)	97.02	93.19–99.02	98.21	94.86–99.61	98.21	94.86–99.61	97.62	94.01–99.33
Specificity (95% CI)	99.18	97.06–99.88	99.59	97.73–99.93	99.78	97.06–99.88	99.81	97.06–99.88
PPV (95% CI)	98.79	95.68–99.82	99.40	96.68–99.90	98.80	95.73–99.80	98.8	95.71–99.82
NPV (95% CI)	97.98	95.34–99.33	98.78	96.47–99.73	98.78	96.46–99.73	98.37	95.89–99.55
LR (+)	118.37	29.76–470.74	239.64	33.89–1694.66	119.82	30.13–476.46	119	29.95–473.60
LR (−)	0.03	0.01–0.07	0.02	0.01–0.06	0.02	0.01–0.06	0.02	0.01–0.06
% accuracy	98.3		99		98.7		98.5