BioMed Research International / 2015 / Article / Tab 3 / Research Article
Growth Pattern of Clear Cell Renal Cell Carcinoma in Patients with Delayed Surgical Intervention: Fast Growth Rate Correlates with High Grade and May Result in Poor Prognosis Table 3 Published series on the natural history of renal masses.
Year Patients/lesions ( Mean age (years) Mean initial MTD (cm) Mean follow-up (months) Mean LGR (cm/year) Mean VGR 3 /year) Progression to metastasis, Pathologic RCC Fujimoto et al. [10 ] 1995 6/6 59.7 2.47 24 0.47 9.7 0 (0) 5/5 Bosniak et al. [11 ] 1995 37/40 65.5 1.73 39 0.36 5.26 0 (0) 22/26 Oda et al. [12 ] 2003 16/16 54a 2.0a 25 0.54a — 0 (0) 16/16* Volpe et al. [7 ] 2004 29/32 71a 2.48 27.9 0.1 3.8 0 (0) 8/9 Wehle et al. [13 ] 2004 29/29 70 1.83 32 0.12 — 0 (0) 3/4 Kato et al. [5 ] 2004 18/18 56.5 2.0 27 0.42 4.4 0 (0) 18/18* Lamb et al. [14 ] 2004 36/36 76.1 7.2 27.7 0.39 — 1 (2.8) 23/24 Chawla et al. [15 ] 2006 49/61 71 2.97 36 0.2 — 1 (1.6) 16/21
Youssif et al. [16 ] 2007 35/44 71.8 2.2 47.6 0.21 2.7 2 (5.7) 6/8 Kouba et al. [17 ] 2007 43/46 67 2.92 32.8 0.7 — 0 (0) 12/14 Siu et al. [18 ] 2007 41/47 68 2.0 29 0.27 — 1 (2.4) 10/16 Fernando et al. [19 ] 2007 13/13 80.4 5.01 38.38 0.17 11.97 1 (7.7) 0 Matsuzaki et al. [20 ] 2007 15/15 67 2.2 38 0.06 0.67 0 (0) 3/3 Lee et al. [8 ] 2008 30/30 65.5 2.6 12.6 0.59 19.1 3 (10.0) 30/30* Beisland et al. [21 ] 2009 63/65 76.3 4.3 33 0.66 — 2 (3.2) 15/18 Crispen et al. [22 ] 2009 154/173 69 2.45 31 0.285 17.0 2 (1.3) 52/61 Rosales et al. [23 ] 2010 212/223 71a 2.8a 35a 0.34a — 4 (1.9) 32/40 Hwang et al. [24 ] 2010 56/58 64.3 2.1 22 0.21 1.9 0 (0) 10/15 Jewett et al. [25 ] 2011 127/151 73 2.1 28 0.13 — 1 (0.7) 37/46 Li et al. [4 ] 2012 32/32 52.2 2.14 46 0.8 — 0 (0) 32/32* Mehrazin et al. [26 ] 2014 68/72 68.9 5.3 38.9 0.44 — 0 (0) 16/23 Brunocilla et al. [27 ] 2014 62/64 75 2.0 91.5 0.4 4.6 1 (1.6) 14/16 Total 1171/1271 69.5 2.82 34.6 0.33 9.48 19 (1.6) 380/444 This study 60/61 55 2.32 39.46 0.86 20.96 1 (1.6) 61/61
