Mammalian Cell Culture Process for Monoclonal Antibody Production: Nonlinear Modelling and Parameter Estimation

Table 5

Kinetic parameter estimates obtained via the multistep PSO approach.

Kinetic parameters	Estimated values
[pmol/(cell h)]	8.443 10^−4
[pmol/(cell h)]	2.481 10^6
[pmol/(cell h)]	3.968 10^5
[pmol/(cell h)]	1.090 10^2
[pmol/(cell h)]	7.283
[pmol/(cell h)]	3.337 10^5
[pmol/(cell h)]	3.977 10^3
[pmol/(cell h)]	6.697 10^−6
[pmol/(cell h)]	3.261 10^4
[mM]	8.989 10^5
[mM]	6.495 10^4
[mM]	3.723 10^4
[mM]	7.076 10^2
[mM]	2.782 10^3
[mM]	0.019
[mM]	2.719 10^4
[mM]	9.324 10^3
[mM]	0.537
[mM]	6.683 10^5
[mM]	1.920 10^3
[mM]	4.488 10^4
	0.043
	0.067