Mammalian Cell Culture Process for Monoclonal Antibody Production: Nonlinear Modelling and Parameter Estimation

Table 6

Kinetic parameter estimates obtained by Gao et al. [27] and by Baughman et al. [4], respectively.

Kinetic parameters	Values (Gao et al. [27]) (exponential phase)	Values (Gao et al. [27]) (decline phase)	Values (Baughman et al. [4])
[pmol/(cell h)]	0.008	−0.0033	8.85 10^−4
[pmol/(cell h)]	0.0191	0.0058	1.12 10^6
[pmol/(cell h)]	0.0023	−0.0014	1.1 10^5
[pmol/(cell h)]	0.0081	0.0057	1.97 10^−2
[pmol/(cell h)]	−0.01	0.0056	4.95
[pmol/(cell h)]	−0.011	0.0029	1.34 10^5
[pmol/(cell h)]	0.6429	0.0573	1.36 10^3
[pmol/(cell h)]	0.0046	0.0077	1 10^−5
[pmol/(cell h)]	0.0731	0.0113	1.83 10^4
[mM]	0.01	0.01	1.63 10^5
[mM]	0.01	0.01	1.08 10^4
[mM]	0.01	0.01	1.44 10^4
[mM]	0.001	0.001	9.64 10^2
[mM]	0.001	0.001	1.04 10^3
[mM]	0.001	0.001	5.42 10^−2
[mM]	0.01	0.01	3.03 10^3
[mM]	0.01	0.01	6.39 10^3
[mM]	0.01	0.01	3.73 10^−1
[mM]	0.01	0.01	3.23 10^5
[mM]	0.001	0.001	7.42 10^3
[mM]	0.001	0.001	4.45 10^3
	0.0399	0.0399	3.22 10^−2
	0.06	0.06	4.99 10^−2