N-Acetylneuraminic Acid Supplementation Prevents High Fat Diet-Induced Insulin Resistance in Rats through Transcriptional and Nontranscriptional Mechanisms

Table 1

Food composition and animal groups.

Animal group	Normal pellet (%)	Cholesterol/cholic acid (%)	Palm oil (%)	Starch (%)	Others
Normal	100
HFD	65	5	20	10
HFD + SIM	65	5	20	10	Simvastatin (10 mg/kg BW/day)
HFD + SAL	65	5	20	10	50 mg/kg BW/day sialic acid
HFD + SAH	65	5	20	10	400 mg/kg BW/day sialic acid

Normal pellet was acquired commercially while other diets were made in-house. HFD: high fat diet, SIM: simvastatin, SAL: low dose sialic acid, and SAH: high dose sialic acid.