Riboflavin Arrests Cisplatin-Induced Neurotoxicity by Ameliorating Cellular Damage in Dorsal Root Ganglion Cells

Figure 1

Sample photomicrographs from the thoracic dorsal root ganglia of mice. Control group (a) shows pseudounipolar neuron with centrally placed nucleus and prominent nucleolus (↑) while cisplatin treated group (b) shows relatively small shrunken neuron, smaller nucleolus, and rarified bundle of nerve fibers (N) and prominent neuroglial cells. Riboflavin treated (c) and combination treated (d) groups show neuronal sizes and nucleolar features comparable to control group. All tissue sections were prepared with H&E stain followed by snapping at magnification of 400x. Arrows indicate neurons while stars indicate the nerve fibres.

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