Endothelial Expression of Scavenger Receptor Class B, Type I Protects against Development of Atherosclerosis in Mice

Figure 11

Model for intramural cholesterol flux by HDL. HDL from lumen penetrates EC, enters intimal space, and acquires cholesterol from macrophages through ABCA1, ABCG1, and SR-BI. After esterification by LCAT, cholesteryl esters are delivered to EC by HDL through interaction with SR-BI located in the basolateral membrane. After intracellular hydrolysis of cholesteryl esters by HSL or NCEH, free cholesterol is effluxed from EC by ABCA1, ABCG1, or SR-BI to HDL in the plasma compartment.