Endothelial Expression of Scavenger Receptor Class B, Type I Protects against Development of Atherosclerosis in Mice

Figure 6

Effect of Scarb1 expression in endothelium on distribution of total cholesterol between different lipoprotein fractions in plasma of transgenic females. The plasma from three different lines of transgenic females was compared: LIV11-SCARB1 transgenic mice overexpressing SCARB1 in liver with functioning endogenous Scarb1; LIV11-SCARB1 × Scarb1-KO (expressing SR-BI only in liver); and Tie2-Scarb1 × LIV11-SCARB1 × Scarb1-KO (SR-BI was expressed in liver and endothelium). Normal C57Bl/6N female plasma was included as a control. In each case 350 μL of plasma was collected from 4 to 6 females and fractionated by FPLC.