Endothelial Expression of Scavenger Receptor Class B, Type I Protects against Development of Atherosclerosis in Mice

Table 2

Plasma lipid profiles of normal C57Bl/6N, LIV11-SCARB1 transgenic, LIV11-SCARB1 × Scarb1-KO, and Tie2-Scarb1 × LIV11-SCARB1 × Scarb1-KO females. All animals were kept on normal chow diet.

Genotype	TC	TG	PL	FC	CE	HDL-C
C57Bl/6N females, = 49–99	76 ± 1	80 ± 2	172 ± 4	15 ± 1	60 ± 1	50 ± 2
LIV11-SCARB1, = 21–40	15 ±	38 ±	43 ±	4 ±	10 ±	<3
Ratio control/LIV11-SCARB1	5.2 ± 0.5	2.1 ± 0.2	4.0 ± 0.4	4.0 ± 1.0	6.0 ± 1.0
The effects of endothelial expression of Scarb1 in Scarb1-deficient mice with LIV11-SCARB1 in homozygous condition
Tie2-Scarb1 × LIV11-SCARB1 × Scarb1-KO, = 32–38	29 ±	75 ±	65 ±	7 ±	21 ±	N/A
LIV11-SCARB1 × Scarb1-KO, = 28–32	20 ± 1	52 ± 4	45 ± 2	4 ± 0.5	16 ± 2	N/A
Ratio Tie2-Scarb1 × LIV11-SCARB1 × Scarb1-KO/LIV11-SCARB1 × Scarb1-KO	1.5 ± 0.1	1.5 ± 0.2	1.4 ± 0.1	1.7 ± 0.3	1.4 ± 0.1	N/A

All values are expressed in units of mg/dL. Among the LIV11-SCARB1 females, 17 were homozygous and 23 were heterozygous for the SCARB1 transgene. LIV11-SCARB1 × Scarb1-KO and Tie2-Scarb1 × LIV11-SCARB1 × Scarb1-KO females were homozygous for SCARB1 transgene.
; ; ; ; . Abbreviations for lipids are the same as in Table 1.