Natural Antioxidant Betanin Protects Rats from Paraquat-Induced Acute Lung Injury Interstitial Pneumonia

Figure 1

Influences of betanin on paraquat-induced rat lung parameter changes. (a) Lung/body weight ratio, (b) lung permeability index, (c) BALF PMNs count, (d) MPO activity, (e) SOD activity, (f) MDA level, (g) TNF-α level, (h) IL-1β level, (i) IL-10 level, and (j) NF-κB (p65) DNA-binding activity. Paraquat was injected intraperitoneally at a single dose of 20 mg/kg body weight, and betanin (25 and 100 mg/kg/d) was orally administered 3 days before and 2 days after paraquat administration. Rats were sacrificed 24 hours after the last betanin dosage. ^#, compared to vehicle control; , compared to paraquat control.

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